ea0044p246 | Thyroid | SFEBES2016
Read Martin
, Fong Jim
, Imruetaicharoenchoke Waraporn
, Nieto Hannah
, Modasia Bhavika
, Fletcher Alice
, Thompson Rebecca
, Sharma Neil
, Bacon Andrea
, Watkinson John
, Boelaert Kristien
, Turnell Andrew
, Smith Vicki
, McCabe Christopher
Despite extensive genomic profiling a better understanding of the contributory factors that promote aggressive thyroid cancer is urgently needed. The proto-oncogenes PBF and PTTG have been implicated in thyroid cancer but there is a lack of information regarding their co-expression and specific roles in tumour progression. Separate studies have previously indicated that PBF and PTTG may disrupt pathways associated with the tumour suppressor p53 that are central to DNA-damage r...